Fig. 1

Serum levels of GDF15 in pSS patients. (A) Serum GDF15 levels in patients with primary Sjögren’s syndrome (pSS) and healthy controls (HCs). (B) Area under the receiver operating characteristic (ROC) curve was used to assess the ability of GDF15 level to distinguish between patients with pSS and HCs. The reference curve is also shown. (C) Serum GDF15 levels in anti-SSA negative pSS patients and HCs. (D) ROC curve analysis was used to assess the ability of GDF15 level to distinguish between anti-SSA negative pSS patients and HCs. (E) Serum GDF15 levels in pSS patients with disease duration ≥ 10 years group and disease duration < 10 years group. (F, G) The correlation of serum GDF15 levels with age in HCs (F) and pSS patients (G). Statistical significance is indicated by asterisks: *** p < 0.001.