Fig. 6 | Scientific Reports

Fig. 6

From: Pharmacokinetics of midazolam and hepatic cytochrome P450 3A activity in an in vivo extracorporeal membrane oxygenation rat model

Fig. 6

Simulation of time-course profiles of plasma MDZ concentration obtained using the PPK model for different dosage regimens. A gradual increase in color intensity represents the level of the dose considered (200, 400, and 800 µg/kg). The top panels (a and b) represent the profiles of plasma MDZ concentration over 0–12 h. The lower panels (c and d) represent the profiles of plasma MDZ concentration over 0–3 h.

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