Table 2 Individual pharmacokinetics parameters determined for the in vivo model using a non-compartmental analysis.

From: Pharmacokinetics of midazolam and hepatic cytochrome P450 3A activity in an in vivo extracorporeal membrane oxygenation rat model

Parameter

Midazolam

ECMO

Sham

AUC0→180 min(ng/mL・hr)

17,004.0 ± 3321.9

14,994.1 ± 1502.5

t1/2 (hr)

7.4 ± 15.3

0.88 ± 0.14

CLtot (L/hr)

0.69 ± 0.52

1.05 ± 0.08

Vdss(L)

1.21 ± 0.47

0.92 ± 0.03

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