Fig. 2

Initial structure and molecular dynamics of hPiT2. (A) The transmembrane domain of hPiT2 constructed on the basis of TmPiT, with residues V624, W626, P631, and S637 mapped to the structure. (B) Root mean square deviation (RMSD) values of the wild-type and V624E, W626A, W626R, P631S, and S637R mutant hPiT2 structures.