Fig. 3 | Scientific Reports

Fig. 3

From: Computational molecular characterization of a novel SLC20A2 variant associated with primary familial brain calcification

Fig. 3

Measurement of the TM8 helix kink angles. (A) The kink angle of the TM8 helix is measured by defining two representative vectors. The upper half is defined with residues 626 to 631, and the lower half is defined with residues 632 to 637. (B) The measured TmPiT kink angles in the open (27.6°) and closed (20.7°) states and the wild-type and mutant hPiT2 kink angles were observed using molecular dynamic simulations. The most likely kink angle of the P631S mutant is 19.0°, which is the lowest among all the hPiT2 mutants. This mutant also has the widest range of possible kink angles.

Back to article page