Fig. 4 | Scientific Reports

Fig. 4

From: Computational molecular characterization of a novel SLC20A2 variant associated with primary familial brain calcification

Fig. 4

Residual environments of wild-type and mutant hPiT2. (A-F) An important π-π interaction between W626 and H596 during Pi binding in wild-type hPiT2 is lost in the V624E, W626A, and W626R mutants. A new hydrogen bond is formed between the mutated residue in the V624E mutant and N621, and a similar situation is observed between the mutated residue S637R and E91. A pyrrolidine ring side chain pointed toward the lipid environment in the P631S mutant is lost. 

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