Table 1 Clinical information of IgA nephropathy patients in the study.

Patients ID	Biopsy	Scr	eGFR	Albumin	TCR	Time	eGFR 2#	TCR 2#	Albumin 2#	Sample
Patient 63	M1E1S1T0-C0	74	121.866	40.3	0.87	12	121.584	1.60	48.8	Normal eGFR IgAN 1
Patient 106	M0E0S1T0-C0	57	115.697	41.8	0.28	4	110.196	0.8(g/d)	47.8	Normal eGFR IgAN 1
Patient 16	M1E0S1T0-C0	96	98.317	41.6	0.62	NA	NA	NA	NA	Normal eGFR IgAN 1
Patient 115	M1E0S1T0-C1	51	133.345	33.2	1.26	12	127.071	0.30	40.7	Normal eGFR IgAN 2
Patient 108	M0E1S1T0-C1	49	128.629	35.7	0.99	14	117.972	0.28	43.4	Normal eGFR IgAN 2
Patient 20	M0E1S0T0-C1	64	115.986	36.4	0.83	8	118.216	1.13	45.7	Normal eGFR IgAN 2
Patient 10	M0E1S1T0-C1	75	109.844	40.2	0.41	13	111.638	0.19	39.6	Normal eGFR IgAN 3
Patient 33	M1E1S1T0-C2	86	106.913	38.8	0.66	4	89.55	0.19	40.6	Normal eGFR IgAN 3
Patient 55	M0E1S1T0-C1	60	104.565	37.5	0.91	NA	NA	NA	NA	Normal eGFR IgAN 3
Patient 13	M1E1S1T0-C1	110	84.2	20.4	9.23	NA	NA	NA	NA	Low eGFR IgAN 1
Patient 77	NA	77	82.309	35.6	2.20	15	71.973	0.32	42.1	Low eGFR IgAN 1
Patient 210	M0E0S0T0-C1	81	78.516	40.4	0.33	13	99.491	0.20	45.6	Low eGFR IgAN 1
Patient 67	M0E0S1T0-C0	98	74.994	35.9	0.56	9	88.227	0.41	41.3	Low eGFR IgAN 1
Patient 220	M0E0S1T0-C0	81	71.162	43.1	0.25(g/d)	13	70.151	0.13(g/d)	41.4	Low eGFR IgAN 2
Patient 145	NA	98	66.901	36	0.32	14	65.141	0.11	40.0	Low eGFR IgAN 2
Patient 64	M0E1S0T0-C1	85	61.274	42.6	0.45	NA	NA	NA	NA	Low eGFR IgAN 2
Patient 36	M0E1S0T0-C1	127	56.380	42.6	2.30	1	70.98	0.16	33.3	Low eGFR IgAN 3
Patient 18	M1E0S1T0-C0	144	53.817	37.5	0.66	4	52.492	0.90	38.6	Low eGFR IgAN 3
Patient 240	M0E1S1T2-C0	127	50.650	29.8	3.73	8	67.048	1.99(g/d)	42.9	Low eGFR IgAN 3
Patient 131	M0E0S1T2-C0	209	28.576	36.4	6.45	7	21.951	6.54	32.5	Low eGFR IgAN 3

^aBiopsy: Oxford classification scores, including the crescent score (MEST-C).
^bScr: Serum creatinine concentration at the time of kidney biopsy (µmol/L).
^ceGFR and eGFR 2#: Estimated glomerular filtration rate at the time of biopsy and at the most recent follow-up (mL/min/1.73 m²).
^dAlbumin and Albumin 2#: Serum albumin concentration at the time of biopsy and at the most recent follow-up (g/L).
^eTCR and TCR 2#: Total urinary protein to urinary creatinine ratio at the time of biopsy and at the most recent follow-up (g/g). When listed as g/d, the numerical value represents total daily urinary protein excretion.
^fTime: Interval in months between the biopsy and the latest test records.
^gSample: Indicates patient samples selected for subsequent single-nucleus RNA sequencing (snRNA-seq).

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