Table 2 Univariate and multivariate Cox regression analyses and multicollinearity analysis of PVT in cirrhosis patients with CHB.

Gender

1.367

 Male

-

1.00 (Reference)

 Female

0.720

0.84 (0.33 ~ 2.14)

Baseline HBV DNA level

1.410

 Low

-

1.00 (Reference)

 Moderate

0.891

0.94 (0.39 ~ 2.25)

 High

0.083

0.16 (0.02 ~ 1.28)

HBV DNA level after therapy

1.764

 Low

-

1.00 (Reference)

 Moderate

 < 0.001

5.21 (2.18 ~ 12.45)

 High

0.332

2.73 (0.36 ~ 20.82)

Antiviral responses

2.075

 VR

-

1.00 (Reference)

1.00 (Reference)

 PVR

 < 0.001

22.52 (4.54 ~ 111.66)

0.333

2.48 (0.39 ~ 15.53)

 PNR

0.006

30.09 (2.70 ~ 335.92)

0.051

15.94 (0.99 ~ 257.16)

 VBT

 < 0.001

65.60 (14.79 ~ 290.95)

< 0.001

42.48 (5.02 ~ 359.89)

HCC

2.096

 No

-

1.00 (Reference)

1.00 (Reference)

 Yes

 < 0.001

14.29 (6.03 ~ 33.89)

< 0.001

30.69 (5.50 ~ 171.15)

Spleen size

2.491

 Normal

-

1.00 (Reference)

 Largish

1.000

1.00 (0.00 ~ Inf)

 Large

0.997

931,361,065.72 (0.00 ~ Inf)

Diabetes

1.192

 No

-

1.00 (Reference)

 Yes

0.841

0.81 (0.11 ~ 6.08)

Hypertension

1.333

 No

-

1.00 (Reference)

 Yes

0.644

0.62 (0.08 ~ 4.63)

HBeAg

 Non-reactive

1.00 (Reference)

 Reactive

0.213

0.60 (0.27 ~ 1.34)

HBeAb

 Non-reactive

1.00 (Reference)

 Reactive

0.093

1.94 (0.89 ~ 4.20)

Cirrhosis degree

 < 0.001

2.37 (1.72 ~ 3.27)

2.791

0.069

1.25 (1.09 ~ 1.38)

Antiviral drugs

0.442

1.15 (0.81 ~ 1.64)

1.251

Age

0.002

1.06 (1.02 ~ 1.10)

1.478

0.145

0.96 (0.90 ~ 1.02)

Baseline HBV DNA Loads

0.207

1.00 (1.00 ~ 1.00)

1.410

HBV DNA loads after therapy

0.834

1.00 (1.00 ~ 1.00)

1.764

Portal vein diameter

 < 0.001

13.20 (5.32 ~ 32.75)

2.086

0.121

0.25 (0.04 ~ 1.44)

Spleen major axis

 < 0.001

1.37 (1.26 ~ 1.49)

2.491

< 0.001

1.49 (1.21 ~ 1.84)

Antiviral therapy time

 < 0.001

1.01 (1.01 ~ 1.01)

1.426

AFP

0.100

1.00 (1.00 ~ 1.00)

1.292

D-dimer

 < 0.001

1.01 (1.01 ~ 1.01)

1.852

0.115

0.98 (0.91 ~ 1.01)

APTT

0.967

1.00 (0.94 ~ 1.06)

1.841

INR

0.003

5.24 (1.75 ~ 15.70)

22.777

Fib

0.061

1.78 (0.97 ~ 3.26)

1.743

PT

0.006

1.15 (1.04 ~ 1.27)

22.419

PLT

 < 0.001

0.98 (0.97 ~ 0.99)

2.308

0.145

0.99 (0.90 ~ 1.06)

MPV

0.023

1.49 (1.06 ~ 2.11)

1.234

0.156

0.87 (0.84 ~ 0.98)

ALT

0.752

1.00 (1.00 ~ 1.00)

7.435

AST

0.468

1.00 (1.00 ~ 1.00)

7.724

GGT

0.089

1.00 (1.00 ~ 1.01)

2.110

ALP

 < 0.001

1.01 (1.01 ~ 1.02)

1.565

0.395

1.01 (1.01 ~ 1.01)

T-Bil

0.013

1.01 (1.01 ~ 1.01)

1.515

0.096

1.01 (1.01 ~ 1.01)

HDL

0.030

1.13 (1.01 ~ 1.27)

1.204

0.135

1.03 (1.01 ~ 1.09)

LDL

0.339

0.73 (0.38 ~ 1.39)

17.355

TG

0.399

0.70 (0.31 ~ 1.60)

1.410

TC

0.309

0.82 (0.57 ~ 1.20)

17.907

HBsAg

0.002

1.01 (1.01 ~ 1.02)

1.268

0.007

1.03 (1.01 ~ 1.05)

HBsAb

 < 0.001

1.01 (1.01 ~ 1.02)

1.478

0.004

1.02 (1.01 ~ 1.03)

HBcAb

0.722

0.97 (0.84 ~ 1.13)

1.297