Fig. 2 | Scientific Reports

Fig. 2

From: Insights from meta-analysis and experimental validation identify exosomal miR-146a-5p as a potential biomarker for sporadic amyotrophic lateral sclerosis

Fig. 2

Validation of miR-146a-5p expression in sALS patients and healthy controls. (a) Relative expression of miR-146a-5p in serum-derived exosomes from sALS patients (N = 22) and healthy controls (N = 18), analysed by qRT-PCR. Data was normalized to endogenous levels of miR-103a-3p and plotted as a relative expression [2^-ΔCt]. P-values were calculated using the Mann–Whitney U-test. (b) The Receiver-operating characteristic (ROC) curve analysis for serum-derived exosomal miR-146a-5p in discriminating ALS patients from controls, with Area Under the Curve (AUC) = 0.7917.

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