Fig. 1
Identification of sarcopenia in 28-week-old SAM-P8 mice. (A) Treadmill test, n = 15–25 mice/group. (B) Forelimb grip strength test, n = 12–21 mice/group. (C, D) Representative images of muscle morphology in hindlimb of mice. (E) Muscle weights of gastro, EDL, soleus, n = 10 mice/group. (F) Muscle indexes of gastro, EDL, soleus, n = 10 mice/group. (G) Representative images of H&E staining of gastro, EDL and soleus (200 × magnification). (H) Cross-sectional areas of gastro, EDL, and soleus, n = 5 mice/group, 3 views/sample. Data described are means ± SEMs. Unpaired two-tailed Student’ s t test was applied for statistical comparisons. # p < 0.05, ### p < 0.001 vs. the NC group. EDL, extensor digitorum longus; gastro, gastrocnemius; NC, normal control; SAM-R1, senescence-accelerated mouse resistant 1; SAM-P8, senescence-accelerated mouse prone 8.
