Fig. 5 | Scientific Reports

Fig. 5

From: Osteocyte necroptosis drives osteoclastogenesis and alveolar bone resorption during orthodontic tooth movement

Fig. 5

Tumor necrosis factor-α (TNF-α)-induced osteocyte necroptosis enhances osteoclastogenesis. a Schematic diagram showing the treatment of osteoclast precursors derived from TNF receptor type 1- and 2-deficient (TNFRsKO) mice with medium conditioned by necroptotic primary osteocytes. Representative images (b) and quantification of TRAP-positive multinucleated (≥ 3 nuclei) cells (c) (n = 4). TSZ, TNF-α (T) + SM-164 (S) + zVAD (Z); c.m., conditioned medium. Scale bar = 200 μm. **p < 0.01, ***p < 0.001, ****p < 0.0001.

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