Fig. 6
From: Mathematical mechanistic model representing the cancer immunity cycle under radiation effects
Comparison between mechanistic model (red line) and the experiments of Marciscano et al. (black line). The horizontal axis represents the number of days since the tumor was inoculated into the mouse, and the vertical axis represents the tumor volume. (A) control (isotype); (B) radiation to the tumor (Tumor RT); (C) radiation to the tumor and DLN (T + DLN); (D) anti-PD-1 antibody treatment; (E) anti-PD-1 antibody treatment + radiation to the tumor; (F) anti-PD-1 antibody treatment + radiation to the tumor and DLN; (G) anti-CTLA-4 antibody treatment; (H) anti-CTLA-4 antibody treatment + radiation to the tumor; and (I) anti-CTLA-4 antibody treatment + radiation to the tumor and DLN.
