Table 3 MRI finding of the two groups of patients. SD: standard deviation; SEGA: subependymal giant cell astrocytoma.

From: Genetic screening of tuberous sclerosis complex in Sicily with a focus on neurological manifestations

 

TSC1 patients

TSC2 patients

p value

Tubers

 Absence of tubers

5 (16%)

5 (10%)

NS

 1 to 5 tubers

5 (16.1%)

7 (14%)

NS

 More than 5 tubers

21 (67.8%)

36 (72%)

NS

 Mean size of tubers (SD)

8 mm (3.9)

17 mm (18.3)

< 0.01

 Tubers dimensions range (95% C.I.)

5–20 mm

4–30 mm

NS

 Subependymal nodules

 Absence of subependymal nodules

5(16.1%)

11(22%)

NS

 1 to 5 subependymal nodules

10(32.3%)

2(4%)

NS

 More than 5 subependymal nodules

16(51.6%)

31(62%)

NS

 Average size of subependymal nodules (SD)

3.87 mm (2.09)

9.4 mm (0.9)

< 0.01

 Subependymal nodules dimensions range (95% C.I.)

2–10 mm

5–12 mm

NS

Subependymal giant-cell astrocytomas

 Patients without SEGA

29 (93.6%)

43 (86%)

NS

 1 SEGA

2 (6.4%)

6 (12%)

NS

 2 or more SEGA

0

1 (2%)

NS

 Patients underwent SEGA surgery

1 (50%)

4 (57%)

NS

 Average size Of SEGAs (SD)

1.1 cm (0.2)

1.3 cm (0.15)

NS

 SEGA dimensions range (95% C.I.)

1–1.2 cm

1–1.5 cm

NS

Radial bands

 Presence of radial bands

12 (38.7%)

6 (12%)

0.011

 1 radial band

3 (9.7%)

2 (4%)

NS

 2 or more radial bands

9 (29%)

4 (8%)

0.028

Cerebral cysts

 Absence of cerebral cysts

30 (96.7%)

47 (94%)

NS

 1 cerebral cyst

0

2 (4%)

NS

 2 or more cerebral cysts

1 (3.2%)

1 (2%)

NS

White matter abnormalities

   

 Absence of white matter abnormalities

22 (71%)

37 (74%)

NS

 Limited white matter abnormalities

4 (12.9%)

5 (10%)

NS

 Diffuse white matter abnormalities

5 (16.1%)

8 (16%)

NS