Fig. 5 | Scientific Reports

Fig. 5

From: Intestinal alkaline phosphatase is a receptor for cholesterol-lowering pentapeptide IIAEK and regulates cholesterol homeostasis in mice

Fig. 5

Mechanism of specific interaction between IIAEK and mouse IAP (Akp3). (a) Overall structure of the IIAEK (Ile-Ile-Ala-Glu-Lys) (salmon pink)–mouse IAP (gene name: Akp3) dimer (gray) complex. Green: Surface of the mouse IAP interacting with IIAEK. (b) Detailed view of the interaction between IIAEK (salmon pink) and mouse IAP. (c) 2D diagram of the network of IIAEK-mouse IAP interaction. (d) Overall structure of the natural substrate of IAP [Pyridoxal 5′-phosphate (PLP)] (silver)–human IAP dimer (gray) complex. Green: the surface of IAP interacting with PLP. (e) Detailed view of the interaction between PLP (yellow) and mouse IAP. (f) 2D diagram of the network of PLP-mouse IAP interaction. (g) Detailed view of overlapping IIAEK-mouse IAP interactions and PLP-mouse IAP interactions. (h) Virtual docking simulation of IIAEK-mouse IAP interactions or PLP-mouse IAP interactions.

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