Fig. 7 | Scientific Reports

Fig. 7

From: Intestinal alkaline phosphatase is a receptor for cholesterol-lowering pentapeptide IIAEK and regulates cholesterol homeostasis in mice

Fig. 7

Mechanism of specific interaction between IIAEK and human IAP. (a) Overall structure of the IIAEK (Ile-Ile-Ala-Glu-Lys) (pink)–human IAP dimer (gray) complex. Green: Surface of human IAP interacting with IIAEK. (b) Detailed view of the interaction between IIAEK (pink) and human IAP. (c) 2D diagram of the network of IIAEK-human IAP interaction. (d) Overall structure of the PLP (yellow)–human IAP dimer (gray) complex. Green: Surface of human IAP interacting with PLP. (e) Detailed view of the interaction between PLP (yellow) and human IAP. (f) 2D diagram of the network of PLP-hIAP interaction. (g) Detailed view of overlapping of IIAEK-human IAP interactions and PLP-human IAP interactions. (h) Virtual docking simulation of IIAEK-human IAP interactions or PLP-human IAP interactions.

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