Table 4 A list of 10 out of 30 promising drug-disease associations supported by shared pathways and protein complexes, and clinical trials.
From: Improving computational drug repositioning through multi-source disease similarity networks
No. | Drug ID (KEGG ID) | Drug Name | Disease ID (MIM ID) | Disease Name | Shared Pathways (KEGG ID) | Shared Complexes (CORUM ID) | ClinicalTrials.gov (NCT ID) |
|---|---|---|---|---|---|---|---|
1 | D00059 | Levodopa (JP18/USP/INN); Dopar (TN) | 181,500 | SCHIZOPHRENIA; SCZD | map04015, map04020, map04024, map04080, map04540, map04728 | 7235 | NCT01636037 |
2 | D00067 | Estrone (JAN/USP/INN); Estrone (TN) | 114,480 | BREAST CANCER | map04915, map04917, map04919, map05200, map05205, map05224 | 2670, 8465 | NCT01089049, NCT00522262 |
3 | D00075 | Testosterone (JAN/USP); Androderm (TN); Androgel (TN); Axiron (TN); Striant (TN); Testim (TN) | 176,807 | PROSTATE CANCER | map04114, map05200, map05215 | 2159, 2160, 6087, 6206, 6450, 6451, 8332, 8442 | NCT04558866, NCT05081193, NCT01187485, NCT04424654, NCT03716739, NCT02286921, NCT03522064, NCT04363164, NCT00853697, NCT02090114, NCT01084759, NCT00515112, NCT04134130, NCT02995330, NCT01750398, NCT03554317, NCT03516812, NCT00587431, NCT01978873, NCT00586898, NCT00577980, NCT03734653, NCT05011383, NCT00006044, NCT00588185, NCT05530395, NCT02297386 |
4 | D00181 | Argatroban (USP); Argatroban hydrate (JP18); Novastan (TN) | 601,367 | STROKE, ISCHEMIC | map04072, map04080, map04610, map04611, map04810, map05200 | 8107 | NCT03552354, NCT04275180, NCT00268762, NCT01464788, NCT03740958, NCT03735979, NCT04202549, NCT00153946, NCT02448069 |
5 | D00292 | Dexamethasone (JP18/USP/INN); Decadron (TN); Maxidex (TN) | 181,500 | SCHIZOPHRENIA; SCZD | map04080 | 8317 | NCT01310140 |
6 | D00400 | Valsartan (JP18/USP/INN); Diovan (TN) | 145,500 | HYPERTENSION, ESSENTIAL | map04020, map04022, map04072, map04080, map04261, map04270, map04371, map04614, map04924, map04925, map04927, map04933, map04934, map05200 | 7773, 7927 | NCT01878201, NCT01001572, NCT01122251, NCT00922441, NCT02480764, NCT00437645, NCT02062645, NCT03371797, NCT00254475, NCT00446524, NCT00425373, NCT02058446, NCT01241487, NCT00716950, NCT00591578, NCT01672476, NCT00699192, NCT00696436, NCT02415192, NCT00546754, NCT00338936 |
7 | D00426 | Risperidone (JP18/USP/INN); Risperdal (TN) | 164,230 | OBSESSIVE-COMPULSIVE DISORDER; OCD | map04020, map04024, map04080, map04540, map04726, map04750, map05030, map05034 | 7747 | NCT00389493, NCT05401019, NCT00854919 |
8 | D00454 | Olanzapine (JAN/USP/INN); Zyprexa (TN) | 143,465 | ATTENTION DEFICIT-HYPERACTIVITY DISORDER; ADHD | map04020, map04024, map04080, map04728, map05012, map05030, map05034 | 6815 | NCT00205699, NCT01000402 |
9 | D00472 | Prednisolone (JP18/USP/INN); Delta-cortef (TN) | 181,500 | SCHIZOPHRENIA; SCZD | map04080 | 8317 | NCT03340909, NCT02949232, NCT04323566, NCT01431326, NCT03194815 |
10 | D00493 | Prochlorperazine (JAN/USP/INN); Compro (TN) | 181,500 | SCHIZOPHRENIA; SCZD | map04015, map04024, map04080, map04540, map04728 | 7235 | NCT02600741 |
