Fig. 5 | Scientific Reports

Fig. 5

From: Ionizing radiation triggers the release of mitochondrial DNA into the cytosol as a signal of mitochondrial damage

Fig. 5

Co-localization of TFAM and cGAS in irradiated cells. (a) Images of TFAM (red), cGAS (green), and nuclear (blue) staining of nonirradiated control and 5-Gy-irradiated TIG-3 cells. The arrow and arrowhead indicate TFAM-negative and TFAM-positive cGAS, respectively. Scale bar is 50 μm. (b) The number of cells positive for both TFAM and cGAS is shown in the right graphs. The asterisk indicates a significant increase in in the number o cGAS in irradiated cells compared to nonirradiated cells (*p < 0.05, **p < 0.01).

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