Table 1 Pharmacodynamic parameters related to the hypoglycemic effects in STZ induced diabetic Wistar rats following SC insulin administration & oral administration of the studied formulations.

From: Effects of piperine on intestinal permeation, pharmacodynamics and pharmacokinetics of insulin loaded chitosan coated solid lipid nanoparticles in rats

 

Group 4 (SC insulin 5 IU)

Group 5 (F1)

Group 6 (F2)

Group 7 (F3)

Group 8 (F4)

AUC

3069.5 ± 27.42

3624.875 ± 32.24

4862.125 ± 25.56

2567.25 ± 36.23

3103.625 ± 34.12

% Cumulative hypoglycemia

58.69 ± 0.4

51.22 ± 0.1

34.57 ± 0.2

65.45 ± 0.3

58.23 ± 0.1

PA (%)

100

16.58 ± 0.3

13.06 ± 0.2

12.91 ± 0.21

10.87 ± 0.31

Tmax (h)

4

6

6

6

6

  1. Each value is expressed with ± standard deviation (n = 5).
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