Fig. 3 | Scientific Reports

Fig. 3

From: RBM47 functions as an anti-oncogene by regulating expression and alternative splicing of cell proliferation and apoptosis associated genes in colorectal cancer cells

Fig. 3

RBM47 broadly regulate expression of cell cycle and apoptosis associated genes in HTC116 cells. (A) The Scatter plot exhibiting the most enriched GO biological process results of the up-regulated DEGs. (B) The Scatter plot exhibiting the most enriched GO biological process results of the down-regulated DEGs. (C) The Scatter plot exhibiting the most enriched KEGG pathway results of the up-regulated DEGs. (D) The Scatter plot exhibiting the most enriched KEGG pathway results of the down-regulated DEGs. (E) Clustering heatmap showing the DEGs involved in apoptosis pathway. (F) Clustering heatmap showing the DEGs involved in cell cycle pathway. (G) Bar plot showing the expression pattern and statistical difference of DEGs for some important genes. (H) Bar plot showing the RT-qPCR results and statistical difference of DEGs in (G) by ActD treatment. (I) The same as (H) but for TERT gene. Error bars represent mean ± SEM. **** P-value < 0.0001, *** P-value < 0.001, ** P-value < 0.01, * P-value < 0.05.

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