Fig. 2
(A) Quantitative analysis of 68Ga-SC691 and 68Ga-PSMA-11 uptake was performed by measuring the SUVmean in selected normal organs (salivary glands, liver, spleen, kidneys, and small intestine), urinary bladder, and blood pool. Data are presented as bar graphs with error bars representing standard deviations. Compared to 68Ga-PSMA-11, 68Ga-SC691 showed significantly lower uptake in all evaluated normal organs (P = 0.002). In contrast, higher activity of 68Ga-SC691 was measured in the urinary bladder, indicating faster renal excretion, the elevated activity of 68Ga-SC691 in the blood pool suggested a potentially slower plasma clearance rate (P = 0.002). (B) Quantitative analysis of 68Ga-SC691 and 68Ga-PSMA-11 uptake was performed by measuring the SUVmax in primary PCa lesions, bone metastases, and lymph nodes metastases. Data are presented as bar graphs with error bars representing standard deviations of the mean. 68Ga-SC691 showed slightly lower SUVmax values compared to 68Ga-PSMA-11 in all three lesion types (primary lesions, bone metastases, and lymph node metastases); however, both radiotracers demonstrated high accumulation within these lesions, with mean SUVmax values exceeding 10.
