Fig. 2
From: Surface keratin 1, a tumor-selective peptide target in human triple-negative breast cancer
Tumor-selective peptides for targeting keratin 1 (K1). (a) Schematic of K1 showing conserved rod region flanked by N-terminal head and C-terminal tail domains. The rod domain is divided into four α-helical units, 1a, 1b, 2a, and 2b linked via L1, L12, and L2 loops. a.a. stands for amino acid. (b) Sequence of peptide p160 and the engineered peptide analogues that display high binding to breast cancer cells and low/minimal binding to non-cancerous cells. X is Norleucine, lower case stands for D-amino acids, and cy stands for cyclic peptide with N- to C-terminal cyclization. (c) Chemical structure of peptide 18–4. L- and D-amino acids are shown in black and blue, respectively.
