Fig. 8
From: Surface keratin 1, a tumor-selective peptide target in human triple-negative breast cancer
Schematic of a TNBC cell showing CSK1-mediated endocytosis of a PDC targeting K1. First, the peptide domain of PDC binds CSK1 (1), leading to endocytosis of PDC (2). Once internalized, the K1-PDC complex undergoes proteolytic cleavage and degradation in lysosomes (3) followed by release of the cytotoxic drug in the cytoplasm (4). Finally, the drug enters the nucleus to intercalate with the DNA (5) eventually causing TNBC cell death.
