Table 8 Aerodynamic performance of Atorvastatin loaded solid SNEDDS delivered using HANDIHALER (mean ± SD, n = 3).

From: Fabrication and evaluation of solidified nanoemulsion designs for systemic delivery of atorvastatin through the lung

Parameter

SF8

SF10

TD (mg)

0.230

0.235

ED (mg)

0.205 ± 0.001

0.198 ± 0.010

DD (mg)

0.165 ± 0.004

0.163 ± 0.007

PD (%)

89.449 ± 2.961

84.537 ± 4.487

PI (%)

71.962 ± 2.109

69.667 ± 3.071

MMAD (µm)

1.515 ± 0.512

1.235 ± 0.129

GSD

3.074 ± 0.365

3.070 ± 0.260

FPD≤ 3 μm (mg)

0.023 ± 0.001

0.026 ± 0.003

FPF

45.443 ± 2.352

54.017 ± 3.294

RF

56.458 ± 1.131

65.507 ± 3.443

FPD≤ 5 μm (mg)

0.028 ± 0.002

0.029 ± 0.001

FPF

55.151 ± 4.564

59.995 ± 1.798

RF

68.475 ± 3.581

72.771 ± 1.564

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