Table 9 Single dose Pharmacokinetic profile of atorvastatin, LIPITOR and solidified SNEDDS (mean ± SD, n = 3).

From: Fabrication and evaluation of solidified nanoemulsion designs for systemic delivery of atorvastatin through the lung

Treatment groups

AUC0 − t (ng/ml*h)

Cmax (ng/ml)

Tmax (h)

t1/2 (h)

MRT (h)

Ke (h− 1)

Atorvastatin

136.13 ± 16.75

11.738 ± 2.241

4 ± 0.00

7.278 ± 1.859

8.735 ± 0.824

0.095 ± 0.003

LIPITOR

220.06 ± 15.60

28.903 ± 3.187

2 ± 0.00

6.051 ± 1.873

7.272 ± 0.984

0.114 ± 0.001

Solidified SNEDDS (SF10)

305.98 ± 26.05

53.146 ± 5.707

2 ± 0.00

6.148 ± 2.628

6.339 ± 0.641

0.112 ± 0.002

  1. MRT: mean residence time. AUC0−t: area under the plasma concentration−time plot from 0 h to time. Ke(h−1): elimination rate constant. t1/2: elimination half−life. Cmax: peak plasma drug concentration. Tmax: time at which Cmax was observed.
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