Fig. 7

Interaction energy heatmaps between MPro residues and top ten phytochemicals. (A) Van der Waals interaction energies (green scale) and (B) Coulombic interaction energies (red scale). Values shown are in kcal/mol, with more negative values (darker colors) indicating stronger interactions. Several residues, including His41, Gly143, and Glu166, form strong interactions with multiple phytochemicals.