Table 4 Clinical characteristics of PH patients where we used iNO and /or PS.

From: Inhaled nitric oxide as an independent intervention to lower the risk of bronchopulmonary dysplasia in preterm infants (< 33 weeks) with pulmonary hypertension within the initial 3 days of life

Variable

iNO + PS (n = 14)

Only iNO (n = 6)

Only PS (n = 16)

No iNO and PS (n = 20)

P-value

Age

29.2 ± 2.6

29.5 ± 2.2

27.7 ± 2.1

28.6 ± 1.7

0.19

Gender(male/female)

7/7

5/1

4/12

14/6

0.02

Weight, (mean ± SD g)

1211 ± 406

1325 ± 419

1010 ± 294

1121 ± 222

0.21

Apgar 1 min, (median, quartile)

5.5 (3.7,8)

7 (3,8)

6 (4,7)

7.5 (5,9)

0.28

Apgar 5 min, (median, quartile)

7.5 (7,9)

9 (6.7,9.2)

8 (7.2,9)

9 (8,9.75)

0.41

ABG PH 1 h after birth, (mean ± SD)

7.240 ± 0.085

7.176 ± 0.172

7.235 ± 0.083

7.292 ± 0.097

0.06

Cesarean, n (%)

8 (57.1)

4 (66.7)

13 (81.3)

10 (50.0)

0.27

Twin, n (%)

5 (35.7)

0

8 (50.0)

5 (25.0)

0.13

SGA, n (%)

3 (21.4)

0

1 (6.3)

2 (10.0)

0.43

PROM, n (%)

4 (28.6)

1 (16.7)

1 (6.3)

5 (25.0)

0.40

GDM, n (%)

0

0

0

0

–

Abortion history, n (%)

7 (50.0)

1 (16.7)

7 (43.8)

7 (35.0)

0.52

RDS, n (%)

11 (78.6)

3 (50)

12 (75.0)

5 (25.0)

0.004

PIH, n (%)

2 (14.3)

1 (16.7)

4 (25.0)

1 (5.0)

0.40

EOS, n (%)

11 (78.6)

5 (83.3)

5 (31.3)

9 (45.0)

0.02

PDA, n (%)

9 (64.3)

2 (33.3)

8 (50.0)

7 (35.0)

0.34

Pneumothorax, n (%)

1 (7.1)

1 (16.7)

3 (18.8)

0

0.23

MAS, n (%)

1 (7.1)

1 (16.7)

0

1 (5.0)

0.47

Before treatment P/F ratio, (mean ± SD)

129.6 ± 47.9

160.8 ± 123.8

114.8 ± 48.2

133 ± 49.54

0.63

24 h After treatment P/F ratio, (mean ± SD)

238.4 ± 76.4

317 ± 111.1

271.9 ± 124.0

280.5 ± 66.4

0.45

Mechanical ventilation, n (%)

13 (92.9)

6 (100)

15 (93.8)

15 (75.0)

0.19

Sildenafil, n (%)

5 (35.7)

5 (83.3)

7 (43.8)

12 (60.0)

0.19

Milrinone, n (%)

9 (64.3)

3 (50.0)

4 (25.0)

6 (30.0)

0.11

Vasoconstrictive drugs, n (%)

3 (21.4)

5 (83.3)

9 (56.3)

8 (40.0)

0.05

BPD, n (%)

2 (14.3)

1 (16.7)

7 (43.8)

16 (80.0)

0.001

ROP, n (%)

2 (14.3)

1 (16.7)

4 (25)

4 (20.0)

0.90

IVH, n (%)

3 (21.4)

1 (16.7)

3 (18.8)

6 (30.0)

0.83

NEC, n (%)

1 (7.1)

0

2 (12.5)

1 (5.0)

0.73

Death, n (%)

0

0

0

0

–

  1. PS = Pulmonary surfactant; BPD = Bronchopulmonary Dysplasia; ROP = Retinopathy of Prematurity; P/F ratio = Partial Pressure of Oxygen(PaO₂)/ Fraction of Inspired Oxygen( FiO₂ ); PH = Pulmonary Hypertension; RDS = Respiratory Distress Syndrome; NEC = Necrotizing Enterocolitis; IVH = Intraventricular Hemorrhage; EOS = Early-Onset Sepsis; SGA = Small for Gestational Age; PROM = Premature Rupture of Membranes; GDM = Gestational Diabetes Mellitus; PIH = Pregnancy-Induced Hypertension; MAS = Meconium Aspiration Syndrome.; iNO = Inhaled nitric oxide.
Back to article page