Fig. 4
From: Chiral pyrimidinyl-piperazine carboxamide derivatives as potent yeast α-glucosidase inhibitors
Binding interactions of compounds (A) 7c, (B) 9c, (C) 21c, and (D) 21b in the active site of α-glucosidase. Key interactions such as hydrophobic, hydrogen, and halogen bonds, as well as π–π stacking and π–cation interactions, are shown in the diagrams. (E) Superimposition of binding modes of compounds 21b and 21c with different configurations at the chiral center.
