Table 1 In vitro α-glucosidase inhibitory activity of compounds 6–22.

Cpd

Chirality

X

Y

IC₅₀ (µM)

Cmpd

Chirality

X

Y

IC₅₀ (µM)

6a

Racemic

3,4-Cl

4-Cl

2.41 ± 0.24^{a, b}

13c

S

4-CF₃

4-Br

1.59 ± 0.23^e

6b

R

3,4-Cl

4-Cl

4.53 ± 0.21^{c, d}

14c

S

4-CF₃

4-CF₃

2.63 ± 0.31^a

6c

S

3,4-Cl

4-Cl

1.82 ± 0.16^e

15c

S

4-CF₃

2,4-Cl

12.0 ± 1.33^j

7b

R

4-CF₃

4-Cl

3.47 ± 0.12^f

16c

S

4-CF₃

3,4-Cl

1.69 ± 0.13^e

7c

S

4-CF₃

4-Cl

1.10 ± 0.11^g

17c

S

4-CF₃

3-NO₂

1.03 ± 0.01^g

8b

R

4-CH₃

4-Cl

7.78 ± 0.15^h

18c

S

4-CF₃

2-OH

5.13 ± 0.49^c

8c

S

4-CH₃

4-Cl

2.42 ± 0.27^b

19c

S

4-CF₃

3-OH

2.05 ± 0.31^{a, b,e}

9b

R

4-OCH₃

4-Cl

23.41 ± 2.40ⁱ

20c

S

4-CF₃

4-OH

3.71 ± 0.49^f

9c

S

4-OCH₃

4-Cl

7.43 ± 0.71^h

21b

R

4-CF₃

3-OH-4-Cl

2.08 ± 0.55^{a, b,e}

10c

S

4-CF₃

2-Cl

4.21 ± 0.25^d

21c

S

4-CF₃

3-OH-4-Cl

0.44 ± 0.13^k

11c

S

4-CF₃

3-Cl

3.45 ± 0.24^f

22c

S

4-CF₃

3-OBn-4-Cl

1.50 ± 0.46^{e, g}

12c

S

4-CF₃

4-F

1.82 ± 0.22^e

Acarbose

-

-

-

817.38 ± 6.3^l