Fig. 1 | Scientific Reports

Fig. 1

From: Characterization of the mutational status of glioblastoma and high-grade astrocytomas in a Latin American cohort

Fig. 1

Oncoplot displaying genetic alterations in 14 genes included in our sequencing panel. Nex-generation sequencing results in 70 patients with high-grade astrocytoma are shown. Groups with different clinical outcomes, histological grade and tumor location for each patient are displayed below. All the multi-hit alterations in TERT promoter gene included the canonical mutations 113 and 135. Multi-hit 2 or more variants were identified, Complex event A copy number variation and another genomic alteration occurred simultaneously, Amp Gene amplification, Del Gene deletion, IDH Isocitrate Dehydrogenase, TERTp Telomerase Reverse Transcriptase Promoter, TMB Tumor mutational burden.

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