Table 1 MCT4 expression in cytoplasm, plasma membrane, and stromal cells stratified by KRAS mutation status.

From: Exploring the role of monocarboxylate transporter 4 in diverse KRAS mutation subtypes of colorectal Cancer

Cellular location

KRAS State

Patients(n)

MCT4 degree

P*

P&

-

+

++

+++

Cytoplasm

WT

38

0

28

10

0

 

Control

G12D

13

0

2

10

1

 

0.0022**

G12V

13

0

5

5

3

 

0.0292*

G13D

11

0

3

5

3

 

0.0056**

13 codon (G13D) vs. 12 codon (G12D/V)

0.7836

 

G13D vs. G12D

> 0.9999

 

G13D vs. G12V

> 0.9999

 

Plasma membrane

WT

38

1

14

19

4

 

Control

G12D

13

0

1

6

6

 

0.0247*

G12V

13

0

3

2

8

 

0.0168*

G13D

11

0

0

0

11

 

< 0.0001****

13 codon (G13D) vs. 12 codon (G12D/V)

0.0116*

 

G13D vs. G12D

0.0213*

 

G13D vs. G12V

0.0692

 

Stromal cells

MUT vs. WT

0.0005***

 

WT

38

17

5

17

-

 

Control

G12D

13

0

5

8

-

 

0.2045

G12V

13

1

3

9

-

 

0.1367

G13D

11

0

0

11

-

 

0.0019**

  1. Staining intensity scale: − = Negative (no staining), += Weak staining, ++ = Moderate staining, +++ = Strong staining; P&: Adjusted P Value of Dunn’s multiple comparisons test; P*: P Value of Mann-Whitney U test; *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001
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