Table 3 MIC/MBC and GM MIC values (µM) of E2P and its derivatives.
Peptide | Gram-positive bacteria | Gram-negative bacteria | GM MIC a | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
S. aureus ATCC 6538 | MRSA NCTC 12,493 | E. faecalis NCTC 12,697 | E. coli ATCC 8739 | E. coli NCTC 13,846 | E. coli ATCC 2340 | E. coli ATCC 2469 | K. pneumoniae ATCC 43,816 | A. baumannii ATCC BAA 747 | P. aeruginosa ATCC 27,853 | G + | G- | all | |
E2P | 2/2 | 1/1 | 1/1 | 1/1 | 2/2 | 1/1 | 1/1 | 1/1 | 1/1 | 1/1 | 1.3 | 1.1 | 1.2 |
1 | 32/64 | > 128 | > 128 | 4/4 | 8/8 | 8/8 | 8/8 | 128/128 | 8/8 | 32/32 | 128 | 13.1 | 26 |
2 | 16/32 | > 128 | > 128 | 4/4 | 8/8 | 16/16 | 8/8 | 128/128 | 8/8 | 8/16 | 101.6 | 11.9 | 22.6 |
3 | 128/128 | > 128 | > 128 | 16/16 | 16/16 | 32/32 | 16/16 | > 128 | 32/32 | 32/64 | 203.2 | 32 | 55.7 |
4 | > 128 | > 128 | > 128 | > 128 | > 128 | > 128 | > 128 | > 128 | > 128 | > 128 | 256 | 256 | 256 |
5 | > 128 | > 128 | > 128 | > 128 | > 128 | > 128 | > 128 | > 128 | > 128 | > 128 | 256 | 256 | 256 |
6 | 16/32 | > 128 | > 128 | 8/8 | 8/8 | 8/32 | 4/4 | > 128 | 4/4 | 4/8 | 101.6 | 9.8 | 19.7 |
7 | 4/8 | 32/32 | 32/64 | 2/2 | 4/4 | 4/4 | 4/4 | 8/8 | 2/2 | 4/4 | 16 | 3.6 | 5.6 |
