Table 4 MIC/MBC values (µM) of E2P and its derivatives against E. coli ATCC 8739 in salts and serum environments.

From: Enhancing the selectivity and conditional sensitivity of an antimicrobial peptide through cleavage simulations and homoarginine incorporation to combat drug-resistant bacteria

Peptide

Control

Physiological salts

Serum

MIC/MBC

K+

Ca2+

Na+

Mg2+

Zn2+

Fe3+

NH4+

10%

20%

E2P

1/1

1/1

8/16

1/1

2/2

2/4

2/2

1/1

1/1

2/4

1

4/4

4/4

> 128

64/64

16/32

8/8

8/8

8/64

16/32

32/64

2

4/4

4/4

128/> 128

64/64

16/16

8/8

8/8

8/16

8/16

32/32

3

16/16

8/8

> 128

128/128

32/32

16/16

16/16

16/16

32/64

64/64

4

> 128

> 128

> 128

> 128

> 128

> 128

> 128

> 128

> 128

> 128

5

> 128

> 128

> 128

> 128

> 128

> 128

> 128

> 128

> 128

> 128

6

8/16

8/8

> 128

4/8

32/32

4/4

8/8

4/4

4/4

8/8

7

2/2

2/2

64/64

8/16

8/8

4/4

2/4

2/2

4/4

8/16

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