Fig. 1 | Scientific Reports

Fig. 1

From: Examination of an iPSC model of human eye development reveals progressive emergence of critical embryonic cell types

Fig. 1

Overview of human iPSC-derived SEAM differentiation. (a) Workflow for generating SEAM cultures from human iPSCs. SEAM cultures form 4 concentric zones over the course of a 28-day differentiation protocol, each consisting of cells analogous to ocular cell types found in the developing human eye. Immunostaining and transcriptomic profiling were performed at Day 0, 14 and 28. (b) Individual zones (dotted lines) and lens clusters are visually distinguishable at 28 days under differentiation conditions. Scale bar, 200 μm.

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