Fig. 2 | Scientific Reports

Fig. 2

From: Examination of an iPSC model of human eye development reveals progressive emergence of critical embryonic cell types

Fig. 2

Temporal profile of SEAM growth and differentiation. (a) Representative images of an individual SEAM (SEAM 9) undergoing differentiation at Day 0 (asterisk), 4, 7, 14, 21 and 28. (b) Overall area of individual SEAMs assessed across several time points (Day 0: 2224.8 μm2 ± 1264.1; Day 7: 35,644.0 μm2 ± 8232.6; Day 14: 36,319.7 μm2 ± 8763.7; Day 21: 25,369.5 μm2 ± 11,124.4; Day 28: 31,499.7 μm2 ± 19,229.3). SEAM 9 indicated with an arrow for reference. (c) Comparison of the overall area of each distinct zone (Zones 1, 2 and 3) at each time point. (d) Schematic illustrating SEAM growth over the course of the 28-day differentiation process. n = 12 SEAMs. One-way ANOVA, values represent mean ± SD; **** p < 0.0001. Scale bar, 200 μm.

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