Fig. 8 | Scientific Reports

Fig. 8

From: Examination of an iPSC model of human eye development reveals progressive emergence of critical embryonic cell types

Fig. 8

Cell type-specific differentiation programs at Day 28 are mediated by signaling interactions across clusters. (a, b) Gene Set Enrichment Analysis (GSEA) analysis of cluster-specific DEGs identified significantly enriched (FDR < 0.05) biological processes (a) and canonical pathways (b) associated with each cell population. Dot size represents the percentage of cells associated with each term. Color scale represents adjusted p values. (c) Global ligand-receptor interaction plots infer cell–cell communication networks across clusters that are common between Day 14 and Day 28, or uniquely enriched at Day 28 (KLK signaling, box). KE, KEGG pathway50; PID, Pathway Interaction Database; REA, Reactome; WP, WikiPathways.

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