Fig. 4
Expression analysis of TREX1 gene in RA patients. (A) Significant downregulation of TREX1 gene was observed in RA compared to controls. (B) Non-significant difference in the expression level of the TREX1 gene was observed in different gender (males vs. females) and age group (< 45years vs. > 45years) of RA patients. (C) Significant downregulated expression level of the TREX1 gene was observed in different clinicopathological parameters of RA patients such as Anti-CCP, ESR, and CRP. (D) Significant downregulated expression level of the TREX1 gene was observed in patients using the methotrexate compared to patients using biologics. Level of significance p < 0.05.
