Table 3 Genotype and allele frequencies of DNA damage pathway gene SNPs in RA patients and controls.

PARP1 SNP Val762Ala

T allele

470

764

1

1

C allele

530

236

3.65(3.1–4.42)

< 0.0001

TT

130(26%)

318(64%)

1

1

TC

210(42%)

128(26%)

2.10(1.60–2.75)

< 0.0001

CC

160(32%)

54(10%)

3.89(2.77–5.45)

< 0.0001

ATM SNP Pro1054Arg

C allele

512

874

1

1

G allele

488

126

6.61(5.28–8.27)

< 0.0001

CC

157(31.4)

396(79.2)

1

1

CG

198(39.6)

82(16.4)

3.34(2.48–4.49)

< 0.0001

GG

145(29.0)

22(4.4)

8.87(5.55–14.18)

< 0.0001

TP53 SNP Ala138Val

C allele

480

816

1

1

T allele

520

184

4.81(3.92–5.88)

0.0001

CC

103(20.6)

329(63.6)

1

1

CT

274(54.8)

158(32.2)

2.23(1.73–2.87)

< 0.0001

TT

123(24.6)

13(4.2)

12.22(6.79–21.98)

< 0.0001

TREX1 SNP Tyr177Tyr

A allele

489

763

1

1

G allele

451

237

2.96(2.44–3.61)

< 0.0001

AA

132(26.4)

298(59.6)

1

1

AG

225(45.0)

167(33.4)

1.63(1.27–2.11)

< 0.0002

GG

113(22.6)

35(07.0)

3.88(2.59–5.80)

< 0.0001