Table 3 Symptom improvement of participants.

From: Addition of bedtime lafutidine inhibits nocturnal acid-breakthrough and improves sleep quality in gastroesophageal reflux disease patients on esomeprazole: a randomized controlled trial

N = 39

Group

Baseline

After treatment

P-value

GERD-Q

LAF& ESO

12.0 (11.0, 14.0)

8.0 (5.0, 10.0)

 < 0.001

 

ESO

11.5 (10.3, 12.0)

8.5 (5.3, 11.8)

0.010

RDQ

LAF& ESO

13.0 (9.0, 18.0)

9.0 (5.0, 12.0)

0.001

 

ESO

16.5 (10.0, 19.0)

12.5 (7.0, 14.8)

0.004

RSI

LAF& ESO

6.0 (4.0, 14.0)

3.0 (2.0, 6.0)

 < 0.001

 

ESO

6.0 (4.0, 13.0)

5.0 (2.3, 8.0)

0.002

Heartburn -daytime

LAF& ESO

7.0 (0.0, 20.0)

0.0 (0.0, 8.0)

0.005

ESO

12.0 (0.0, 27.0)

0.5 (0.0, 12.0)

0.001

Heartburn -nighttime

LAF& ESO

8.0 (0.0, 24.0)

2.0 (0.0, 10.0)

 < 0.001

ESO

12.0 (0.3, 28.0)

2.0 (0.0, 12.0)

0.004

Regurgitation -daytime

LAF& ESO

6.0 (2.0, 15.0)

2.0 (0.0, 8.0)

0.014

ESO

8.0 (0.0, 23.0)

4.0 (0.0, 12.0)

0.008

Regurgitation -nighttime

LAF& ESO

8.0 (2.0, 21.0)

2.0 (0.0, 6.0)

 < 0.001

ESO

10.0 (0.0, 27.0)

3.0 (0.0, 11.0)

 < 0.001

  1. GERD-Q: GERD-questionnaire; RDQ: Reflux disease questionnaire; RSI: Reflux symptom index.