Table 1 Clinical evaluation of the in-vivo rabbit model generated.

From: Comparative assessment of structural and tear film alterations in rabbit meibomian gland dysfunction models using chemical and electrocauterization techniques

Study Group

Pre-op

Post- op D7

Post- op D14

Post- op D30

Post- op D60

Post- op D90

Grading Scale

CC

EC

CC

EC

CC

EC

CC

EC

CC

EC

CC

EC

LMV

UL

0.0 ± 0.0

0.0 ± 0.0

0.9 ± 0.3*

1.3 ± 0.5**

1.2 ± 0.4**

1.8 ± 0.4**

1.7 ± 0.5**

2 ± 0.6**

1.7 ± 0.5**

1.7 ± 0.6**

2 ± 0**

2 ± 0**

LL

0.0 ± 0.0

0.0 ± 0.0

0.9 ± 0.3*

1.1 ± 0.3**

1 ± 0*

1.3 ± 0.5**

1.2 ± 0.4**

1.7 ± 0.8**

1 ± 0**

1.7 ± 0.5**

1 ± 0**

1.7 ± 0.5**

LMI

UL

0.0 ± 0.0

0.0 ± 0.0

0.0 ± 0.0

0.3 ± 0.3

0.8 ± 0.4*

0.7 ± 0.5*

1 ± 0*

0.8 ± 0.4*

1 ± 0*

1 ± 0*

1 ± 0*

2 ± 0*

LL

0.0 ± 0.0

0.0 ± 0.0

0.0 ± 0.0

0.2 ± 0.4

0.3 ± 0.5

0.7 ± 0.5*

0.5 ± 0.5

0.8 ± 0.4*

0.7 ± 0.5*

1 ± 0**

0.7 ± 0.5*

1.3 ± 0.5**

LMT

UL

0.0 ± 0.0

0.0 ± 0.0

0.0 ± 0.0

0.1 ± 0.4

0.2 ± 0.4

0.3 ± 0.5

0.3 ± 0.5

0.7 ± 0.8

0.3 ± 0.5

1 ± 0*

1 ± 0*

1 ± 0*

LL

0.0 ± 0.0

0.0 ± 0.0

0.0 ± 0.0

0.0 ± 0.0

0.3 ± 0.5

0.2 ± 0.4

0.5 ± 0.5

0.3 ± 0.8

0.7 ± 0.5

0.7 ± 0.5

0.7 ± 0.5

0.7 ± 0.5

PGO

UL

0.0 ± 0.0

0.0 ± 0.0

0.0 ± 0.0

0.2 ± 0.4

0.0 ± 0.0

1 ± 0*

0.8 ± 0.4

1.2 ± 0.4**

1.3 ± 0.5**

1.3 ± 0.6**

1.3 ± 0.5**

2 ± 0**

LL

0.0 ± 0.0

0.0 ± 0.0

0.0 ± 0.0

0.2 ± 0.4

0.2 ± 0.4

0.8 ± 0.4

0.2 ± 0.4

1.2 ± 0.4**

0.7 ± 0.5

1.3 ± 0.5**

1 ± 0*

1.3 ± 0.5**

Meibo score

UL

0.0 ± 0.0

0.0 ± 0.0

0.0 ± 0.0

0.1 ± 0.3

0.7 ± 0.5*

1.2 ± 0.4**

1.2 ± 0.4**

1.2 ± 0.4**

1.7 ± 0.6*

1.7 ± 0.6*

2 ± 1*

1.7 ± 0.6*

LL

0.0 ± 0.0

0.0 ± 0.0

0.1 ± 0.3

0.1 ± 0.3

0.3 ± 0.5

1 ± 0*

0.8 ± 0.4**

1.3 ± 0.5**

1 ± 0*

2 ± 0*

1.3 ± 0.6*

2.3 ± 0.6**

Part-al glands

UL

0.0 ± 0.0

0.0 ± 0.0

0.0 ± 0.0

0.1 ± 0.3

0.7 ± 0.5*

1 ± 0*

1.5 ± 0.5**

1.5 ± 0.5**

2 ± 0*

1.7 ± 0.6*

2.3 ± 0.6*

2 ± 0**

LL

0.0 ± 0.0

0.0 ± 0.0

0.2 ± 0.7

0.1 ± 0.3

0.5 ± 0.8

1 ± 0*

1 ± 0.6**

1.5 ± 0.5**

1.3 ± 0.6*

2.3 ± 0.6*

1.7 ± 0.6*

2 ± 0**

Gland drop-out

UL

0.0 ± 0.0

0.0 ± 0.0

0.0 ± 0.0

0.0 ± 0.0

0.0 ± 0.0

0.0 ± 0.0

0.0 ± 0.0

0.2 ± 0.4

0.0 ± 0.0

0.3 ± 0.6

0.7 ± 1.2

1 ± 1

LL

0.0 ± 0.0

0.0 ± 0.0

0.0 ± 0.0

0.0 ± 0.0

0.0 ± 0.0

0.0 ± 0.0

0.0 ± 0.0

0.3 ± 0.8

0.0 ± 0.0

0.3 ± 0.6

0.3 ± 0.6

1.3 ± 1.5

NITBUT

14.21 ± 0.62

14.17 ± 0.88

13.42 ± 0.74*

13.71 ± 1.24

12.37 ± 0.41*

12.18 ± 0.99

11.43 ± 0.76**

9.73 ± 0.27*

9.53 ± 0.40**

9.14 ± 0.2**

9.50 ± 0.37*

8.34 ± 0.48*

CS score

0.33 ± 0.50

0.44 ± 0.53

0.44 ± 0.53

0.78 ± 0.44

1 ± 0.63

1 ± 0.89

1.17 ± 0.41*

1.17 ± 0.41*

1.67 ± 0.58*

2.33 ± 0.58*

2 ± 0*

3 ± 0 *

TMH

0.22 ± 0.05

0.28 ± 0.06

0.16 ± 0.02

0.21 ± 0.04

0.3 ± 0.05

0.14 ± 0.09

0.28 ± 0.09

0.250 ± 0.06

0.30 ± 0.02

0.41 ± 0.08

0.21 ± 0.02

0.3 ± 0.08

ST

18 ± 3.06

21 ± 6.81

21 ± 6.81

18 ± 3.06

17 ± 5.13

25 ± 2.65

14 ± 0.58

22 ± 3.79

17 ± 6.03

20 ± 2.52

15 ± 1.53

18 ± 2.65

Data represented as mean ± standard deviation, ‘*’ indicates p < 0.05; ‘**’ indicates p < 0.001

  1. CC, chemical cauterization group; EC, electrocauterization group; LMV, lid margin vascularity; LMI, lid margin irregularity LMT, lid margin telangiectasia; UL, upper lid; LL, lower lid; PGO, plugging of gland orifices; NITBUT, Non-invasive tear break up time; CS, corneal staining; TMH, tear meniscus height; ST, Schirmer’s test.
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