Table 2 Baseline characteristics before and after propensity score matching of the Normal-or-mild-AKI and Moderate-to-severe-AKI cohorts.
Before matching | After matching | |||||
|---|---|---|---|---|---|---|
Normal-or-mild-AKI (N = 2158) | Moderate-to-severe-AKI (N = 2978) | SMD | Normal-or-mild-AKI (N = 1323) | Moderate-to-severe-AKI (N = 1323) | SMD | |
Age (Years) | 75.00 [63.00, 84.75] | 75.00 [65.00, 83.00] | 0.055 | 75.00 [65.00, 84.00] | 75.00 [65.00, 84.00] | 0.036 |
Gender (Female) | 1000 (46.34%) | 1324 (44.46%) | 0.038 | 590 (44.60%) | 611 (46.18%) | 0.032 |
ahf_first (YES) | 437 (20.25%) | 419 (14.07%) | 0.164 | 260 (19.65%) | 204 (15.42%) | 0.111 |
ICU Score | ||||||
SOFA Score | 3.00 [2.00, 5.00] | 5.00 [3.00, 7.00] | 0.494 | 4.00 [2.00, 6.00] | 4.00 [2.00, 5.00] | 0.249 |
AKI Kidigo | ||||||
0 | 979 (45.37%) | 0 (0.00%) | 3.69 | 524 (39.61%) | 0 (0.00%) | 3.56 |
1 | 1179 (54.63%) | 0 (0.00%) | 799 (60.39%) | 0 (0.00%) | ||
2 | 0 (0.00%) | 1972 (66.22%) | 0 (0.00%) | 986 (74.53%) | ||
3 | 0 (0.00%) | 1006 (33.78%) | 0 (0.00%) | 337 (25.47%) | ||
Surgeries and procedures | ||||||
CABG | 91 (4.22%) | 202 (6.78%) | 0.113 | 79 (5.97%) | 57 (4.31%) | 0.075 |
PCI | 49 (2.27%) | 58 (1.95%) | 0.022 | 28 (2.12%) | 23 (1.74%) | 0.027 |
CRRT | 38 (1.76%) | 112 (3.76%) | 0.122 | 24 (1.81%) | 24 (1.81%) | < 0.001 |
IABP | 50 (2.32%) | 158 (5.31%) | 0.157 | 44 (3.33%) | 46 (3.48%) | 0.008 |
Drug use | ||||||
ACEI/ARB | 685 (31.74%) | 1067 (35.83%) | 0.086 | 474 (35.83%) | 465 (35.15%) | 0.014 |
Anticoagulant | 1858 (86.10%) | 2749 (92.31%) | 0.201 | 1196 (90.40%) | 1169 (88.36%) | 0.066 |
Antiplatelet | 1475 (68.35%) | 2206 (74.08%) | 0.127 | 978 (73.92%) | 909 (68.71%) | 0.116 |
β-Blocker | 1410 (65.34%) | 2208 (74.14%) | 0.193 | 972 (73.47%) | 926 (69.99%) | 0.077 |
Loop diuretic | 1705 (79.01%) | 2617 (87.88%) | 0.24 | 1117 (84.43%) | 1085 (82.01%) | 0.065 |
Positive inotropic | 309 (14.32%) | 654 (21.96%) | 0.199 | 231 (17.46%) | 187 (14.13%) | 0.091 |
Spironolactone | 126 (5.84%) | 208 (6.98%) | 0.047 | 86 (6.50%) | 88 (6.65%) | 0.006 |
Statin | 1396 (64.69%) | 2136 (71.73%) | 0.152 | 922 (69.69%) | 899 (67.95%) | 0.038 |
Vasopressor | 651 (30.17%) | 1694 (56.88%) | 0.56 | 579 (43.76%) | 408 (30.84%) | 0.27 |
Comorbidities | ||||||
CAD | 1174 (54.40%) | 1728 (58.03%) | 0.073 | 782 (59.11%) | 720 (54.42%) | 0.095 |
AFIB | 516 (23.91%) | 800 (26.86%) | 0.068 | 346 (26.15%) | 351 (26.53%) | 0.009 |
Diabetes | 866 (40.13%) | 1226 (41.17%) | 0.021 | 546 (41.27%) | 538 (40.67%) | 0.012 |
Renal disease | 924 (42.82%) | 1212 (40.70%) | 0.043 | 544 (41.12%) | 526 (39.76%) | 0.028 |
Liver disease | 37 (1.71%) | 90 (3.02%) | 0.086 | 26 (1.97%) | 31 (2.34%) | 0.026 |
COPD | 440 (20.39%) | 631 (21.19%) | 0.02 | 271 (20.48%) | 272 (20.56%) | 0.002 |
Stroke | 96 (4.45%) | 236 (7.92%) | 0.145 | 72 (5.44%) | 68 (5.14%) | 0.014 |
Malignancy | 308 (14.27%) | 381 (12.79%) | 0.043 | 187 (14.13%) | 196 (14.81%) | 0.019 |
Vital signs (1st 24 h) | ||||||
MAP (mmHg) | 83.00 [72.00, 94.00] | 80.00 [69.00, 93.00] | 0.14 | 81.00 [70.00, 92.00] | 83.00 [72.00, 95.00] | 0.091 |
Heart rate (bpm) | 85.00 [75.00, 99.00] | 86.00 [74.00, 101.00] | 0.037 | 85.00 [75.00, 100.00] | 85.00 [74.00, 99.00] | 0.025 |
Temperature (℃) | 36.61 [36.39, 36.89] | 36.61 [36.33, 36.94] | 0.006 | 36.61 [36.39, 36.89] | 36.67 [36.39, 36.94] | 0.005 |
Laboratory tests (1st 24 h) | ||||||
WBC (109/L) | 9.80 [7.30, 13.40] | 10.80 [8.00, 14.80] | 0.143 | 10.50 [7.80, 14.20] | 9.90 [7.50, 13.50] | 0.098 |
Hemoglobin (g/dL) | 10.60 [9.00, 12.30] | 10.70 [8.90, 12.30] | 0.014 | 10.60 [9.00, 12.30] | 10.70 [9.05, 12.30] | 0.028 |
Platelet (109/L) | 202.00 [156.00, 261.00] | 196.00 [147.00, 259.00] | 0.054 | 199.00 [150.00, 255.50] | 202.00 [157.00, 258.00] | 0.072 |
Sodium (mmol/L) | 138.00 [135.00, 141.00] | 137.50 [134.00, 140.00] | 0.013 | 138.00 [134.00, 140.00] | 138.00 [135.00, 141.00] | 0.051 |
Potassium (mmol/L) | 4.20 [3.80, 4.70] | 4.30 [3.90, 4.80] | 0.067 | 4.20 [3.80, 4.80] | 4.20 [3.80, 4.70] | 0.044 |
Bicarbonate (mmol/L) | 24.00 [21.00, 27.00] | 24.00 [21.00, 27.00] | 0.106 | 24.00 [21.00, 27.00] | 24.00 [22.00, 27.00] | 0.083 |
Chloride (mmol/L) | 102.00 [98.00, 105.00] | 102.00 [98.00, 106.00] | 0.007 | 102.00 [98.00, 106.00] | 102.00 [98.00, 105.50] | 0.02 |
BUN (mg/dL) | 27.00 [18.00, 45.00] | 27.00 [18.00, 44.00] | 0.022 | 27.00 [18.00, 43.00] | 27.00 [18.00, 43.00] | 0.034 |
Creatinine (mg/dL) | 1.20 [0.90, 1.90] | 1.20 [0.90, 1.90] | 0.051 | 1.20 [0.90, 1.80] | 1.20 [0.90, 1.80] | 0.051 |
eGFR (mL/min/1.73 m2) | 50.35 [30.67, 76.53] | 50.42 [30.01, 74.76] | 0.059 | 50.78 [30.74, 76.24] | 51.99 [32.87, 77.43] | 0.041 |
BNP (tested) | 167 (7.74%) | 263 (8.83%) | 0.04 | 113 (8.54%) | 119 (8.99%) | 0.016 |
TNT (tested) | 1102 (51.07%) | 1490 (50.03%) | 0.021 | 674 (50.94%) | 676 (51.10%) | 0.003 |
CK-MB (tested) | 9.80 [7.30, 13.40] | 10.80 [8.00, 14.80] | 0.143 | 10.50 [7.80, 14.20] | 9.90 [7.50, 13.50] | 0.098 |
