Fig. 5
From: Aerobic exercise alleviates cognitive impairment in T2DM mice through gut microbiota
The exploration on the mechanism of exercise alleviating cognitive impairment in T2DM mice through microbiota. (a,b) Western blot analysis for tight junction proteins (Occludin and ZO1) and their quantification in the colonic mucosa. Proinflammatory factors IL-6 (c) and TNF-α (d) in the hippocampus detected by ELISA. (e,f) Western blot analysis for neurotrophic factors (BDNF and GDNF), synaptic proteins (SYN and PSD95), and (g,h) glucose transporter (GLUT1 and GLUT4) in the hippocampus. The membrane images were cropped from different membranes to remove irrelevant parts (Supplementary Fig. S1). *P < 0.05, **P < 0.005, ***P < 0.001, ****P < 0.0001 versus NC group. #P < 0.05, ##P < 0.005, ###P < 0.001, ####P < 0.0001 versus DM group.
