Table 2 Evaluation of physicochemical properties of KMF-loaded niosome nanoparticles. Measurement of the hydrodynamic diameter of niosome-KMF nanoparticles by dynamic light scattering and assessment of the zeta potential using a zetasizer.
From: The apoptotic and anti-metastatic effects of niosome kaempferol in MCF-7 breast cancer cells
Experiment | Results | Threshold | Acceptance |
|---|---|---|---|
Polydispersity index (PDI) | 0.165 | 0.1 to 0.25 most acceptable 0.25 to 0.5 acceptable 0.5 to 0.75 poor acceptable 0.75 to 1.00 not acceptable | Acceptable |
Zeta potential (Mv) | 33.9 | Zeta potential values > 30 mV and < 60 mV in absolute terms are regarded as indicative of good and outstanding stability, respectively. A zeta potential of > ± 30 mV indicates monodisperse formulations devoid of aggregates. | Acceptable and stable |
SEM | 500 nm | Niosomes often fall within the sub-micron (colloidal) size spectrum. The dimensions of small unilamellar vesicles ranged from 10 to 100 nm, large unilamellar vesicles from 100 to 3000 nm, and multi-lamellar vesicles exceeded 5 μm, with some “giant” vesicles reported to be bigger than 15 μm. | Good |
DLS | 100–500 nm | Good |
