Table 3 Odds ratios (ORs) and 95% confidence intervals (CIs) for the risk of metabolic syndrome according to PRSMetS and lifestyle.

From: Influence of lifestyle risk factors and genetic predisposition on metabolic syndrome risk in Korean adults

 

PRSMetS and lifestyle

p-valuea

Low PRSMetS

(n = 4671)

High PRSMetS

(n = 316)

Unadjusted

1.00 (reference)

1.26 (0.99, 1.59)

0.057

Model 1b

1.00 (reference)

1.24 (0.97, 1.57)

0.082

Model 2c

1.00 (reference)

1.31 (1.03, 1.66)

0.031

 

Ideal lifestyle

(n = 1120)

Intermediate lifestyle

(n = 2847)

Poor lifestyle

(n = 704)

Ideal lifestyle

(n = 74)

Intermediate lifestyle

(n = 211)

Poor lifestyle

(n = 31)

p-valuea

Unadjusted

1.00 (reference)

3.05 (2.54, 3.67)

6.83 (5.46, 8.53)

1.91 (1.10, 3.34)

3.79 (2.74, 5.23)

8.25 (3.96, 17.16)

< 0.0001

Model 1b

1.00 (reference)

2.99 (2.47, 3.62)

7.22 (5.67, 9.18)

1.91 (1.09, 3.34)

3.79 (2.73, 5.27)

8.73 (4.16, 18.32)

< 0.0001

Model 2c

1.00 (reference)

3.09 (2.55, 3.74)

7.47 (5.85, 9.53)

1.88 (1.07, 3.32)

4.25 (3.04, 5.94)

9.35 (4.41, 19.83)

< 0.0001

  1. PRSMetS, PRS for metabolic disease; PRS, polygenic risk score. aOR and 95% CI were obtained using multiple logistic regression analysis. bAdjusted for sex and age. cAdjusted for sex, age, and low-density lipoprotein cholesterol. Healthy lifestyle score was categorized as 6–9 points for ideal lifestyle, 3–5 points for intermediate lifestyle, and 0–2 points for poor lifestyle.
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