Fig. 2
From: SREBP-2 promotes cancer progression through the mevalonate-Akt pathway in non-small cell lung cancer
SREBP-2 knockdown impairs the proliferation, migration and invasion of NSCLC cells. H1299 and PC-9 cells were transfected with NC- or SREBP-2-siRNAs. Expression levels of SREBP-2 in H1299 (A) and PC-9 (B) cells were measured using Western blot analysis. GAPDH served as an internal control. Cell proliferation of H1299 (C) and PC-9 (D) was measured using a CCK-8 assay. Cell migratory and invasive abilities of H1299 (E) and PC-9 (F) were examined using the Transwell method at 48 hour after transfection. Data are presented as the mean ± SD of at least 3 independent experiments. * p < 0.05, ** p < 0.01, *** p < 0.001, compared with the NC group.
