Fig. 6

(a) The growth of wild-type and mutant cells for Minigene after transient transfection for 24 h. (b) After collecting the wild-type and mutant cells for precipitation, RNA was extracted and reverse-transcribed. The target gene was then amplified by PCR. (c) The amplified product was recovered and sequenced. After the c.363 + 668G > C mutation occurred, a 92 bp intron sequence was inserted between c.363 and c.364.