Fig. 2 | Scientific Reports

Fig. 2

From: Hyperbaric oxygen treatment attenuates naloxone-precipitated opioid withdrawal behaviors and alters microglial activity in male and female mice

Fig. 2

HBOT attenuates somatic symptoms of morphine withdrawal in morphine-dependent male and female mice. (A) Schematic of experimental protocol. (B) Wet-dog shakes (WDS) are decreased following HBOT in male and female mice treated with morphine. (C) Forepaw tremors (FPT) are decreased following HBOT in both sexes. (D) Female mice jump more than male mice with no effect of HBOT. (E) Female mice rear more than male mice with no effect of HBOT. (F) Female mice exhibit more horizontal activity than male mice. HBOT decreases horizontal activity in female mice. (G) HBOT decreases fecal boli production in male and female mice and male mice produce more fecal boli than female mice. Data are represented as mean ± SEM. *p < 0.05. n = 8–9/group. White circles/white bars: Morphine-treated HBOT− mice. Purple circles/gray bars: Morphine-treated HBOT+ mice.

Back to article page