Fig. 4 | Scientific Reports

Fig. 4

From: Hyperbaric oxygen treatment attenuates naloxone-precipitated opioid withdrawal behaviors and alters microglial activity in male and female mice

Fig. 4

HBOT has no effect on conditioned aversion and contextual drug seeking behaviors. (A) Schematic for conditioned place aversion (CPA) experimental protocol. (B) CPA was successfully acquired, but there is no difference between HBOT+ (n = 14) and HBOT− (n = 12) groups on CPA score. (C) There is no difference between HBOT+ (n = 14) and HBOT− (n = 12) groups on the amount of time spent in the naloxone-paired chamber. (D) Schematic for conditioned place preference (CPP) experimental protocol. (E) CPP was successfully acquired, but there is no difference between HBOT+ (n = 5) and HBOT− (n = 4) groups on CPP score. (F) There is no difference between HBOT+ (n = 5) and HBOT− (n = 4) groups on the amount of time spent in the morphine-paired chamber. Data are represented as mean ± SEM. *p < 0.05. White circles/white bars: HBOT− male mice. Purple circles/gray bars: HBOT+ male mice.

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