Table 1 Characteristics of the study population.

From: Inflammation mediated glycolipid dysregulation in coronary microvascular disease pathogenesis

Variables

Total

(n = 241)

Quartiles of TG/HDL

p value

Q1 (n = 60)

Q2 (n = 60)

Q3 (n = 60)

Q4 (n = 61)

 

Baseline characteristic

Gender

0.02

Male, n (%)

139 (57.44)

33 (55.00)

25 (41.67)

40 (65.57)

41 (67.21)

 

Female, n (%)

103 (42.56)

27 (45.00)

35 (58.33)

21 (34.43)

20 (32.79)

 

Age, years

66 [58, 71]

67.00 [57.75,72.00]

67.00 [59.00,71.50]

67.00 [59.00,73.00]

62.00 [55.00,69.00]

0.03

CMVD, n (%)

0.02

YES

150 (61.98)

28 (46.67)

36 (60.00)

41 (67.21)

45 (73.77)

 

NO

92 (38.02)

32 (53.33)

24 (40.00)

20 (32.79)

16 (26.23)

 

CAD, n (%)

     

0.63

YES

163 (67.36)

43 (71.67)

37 (61.67)

43 (70.49)

40 (65.57)

 

NO

79 (32.64)

17 (28.33)

23 (38.33)

18 (29.51)

21 (34.43)

 

Risk factors

Smoking, n (%)

77 (31.82)

14 (23.33)

16 (26.67)

20 (32.79)

27 (44.26)

0.07

Drinking, n (%)

71 (29.34)

15 (25.00)

12 (20.00)

18 (29.51)

26 (42.62)

0.04

Hypertension, n (%)

179 (73.97)

42 (70.00)

43 (71.67)

46 (75.41)

48 (78.69)

0.70

Hyperlipidemia, n (%)

139 (57.44)

34 (56.67)

32 (53.33)

32 (52.46)

41 (67.21)

0.33

Diabetes, n (%)

85 (35.12)

15 (25.00)

20 (33.33)

24 (39.34)

26 (42.62)

0.19

Medication during perioperation

Aspirin, n (%)

234 (96.69)

57 (95.00)

58 (96.67)

60 (98.36)

59 (96.72)

0.75

Clopidogrel, n (%)

221 (91.32)

57 (95.00)

51 (85.00)

58 (95.08)

55 (90.16)

0.15

Statin, n (%)

203 (83.88)

54 (90.00)

48 (80.00)

49 (80.33)

52 (85.25)

0.39

Nitrate, n (%)

63 (26.03)

17 (28.33)

17 (28.33)

18 (29.51)

11 (18.03)

0.43

CCB, n (%)

105 (43.39)

19 (31.67)

29 (48.33)

30 (49.18)

27 (44.26)

0.19

Physical examination

Systolic pressure (mmHg)

134.00 [123.00, 147.00]

132.00 [120.00,142.25]

140.50 [127.00,151.00]

135.00 [124.00,149.00]

128.00 [119.00,144.00]

0.02

Diastolic pressure (mmHg)

81.00 [74.00, 88.00]

80.00 [74.50,86.50]

78.00 [72.00,88.25]

81.00 [74.00,87.00]

82.00 [78.00,89.00]

0.29

Heart rate (bpm)

73.00 [65.00, 82.00]

71.50 [64.00,79.00]

70.00 [64.00,80.00]

70.00 [63.00,81.00]

78.00 [71.00,86.00]

0.01

Inflammatory indexes

CRP (mg/L)

1.00 [0.64, 1.96]

0.90 [0.52,1.54]

0.90 [0.60,1.53]

0.98 [0.75,2.01]

1.57 [0.81,3.13]

< 0.01

CLR

0.67 [0.38, 1.33]

0.57 [0.33,0.99]

0.66 [0.33,1.03]

0.67 [0.49,1.36]

1.01 [0.52,1.75]

0.032

IBI

2.65 [1.46, 5.60]

1.90 [1.17,3.81]

2.71 [1.14,5.07]

2.73 [1.91,6.67]

4.06 [1.61,7.55]

0.01

Laboratory indexes

TG/HDL

1.20 [0.85, 1.70]

0.60 [0.52,0.75]

1.01 [0.91,1.12]

1.41 [1.30,1.58]

2.45 [1.98,3.30]

< 0.01

Monocyte, 109/L

1.57 [1.29, 1.97]

1.58 [1.16,1.89]

1.63 [1.31,1.95]

1.57 [1.30,1.96]

1.56 [1.32,2.17]

0.67

Lymphocyte, 109/L

4.02 [3.20, 5.09]

3.71 [2.71,4.67]

4.08 [3.23,4.81]

4.36 [3.48,5.80]

4.00 [3.29,5.20]

0.03

Neutrophils, 109/L

0.38 [0.30, 0.47]

0.34 [0.27,0.45]

0.36 [0.31,0.45]

0.42 [0.35,0.51]

0.38 [0.30,0.48]

0.03

Troponin (ng/mL)

1.20 [0.85, 1.70]

0.60 [0.52,0.75]

1.01 [0.91,1.12]

1.41 [1.30,1.58]

2.45 [1.98,3.30]

0.07

CK-MB (ng/mL)

1.71 [1.19, 2.32]

1.87 [1.41,2.49]

1.47 [1.15,1.87]

1.83 [1.25,2.53]

1.59 [1.11,2.29]

0.05

Myoglobin (ng/mL)

31.50 [25.45, 39.95]

34.41 [27.25,43.80]

30.06 [25.85,34.24]

31.50 [25.10,38.10]

30.17 [25.00,40.00]

0.33

BNP (pg/mL)

72.95 [36.32, 169.75]

88.70 [47.98,194.00]

84.55 [47.72,179.50]

63.35 [30.10,213.30]

56.20 [25.96,111.50]

0.04

ALT (U/L)

18.50 [13.20, 26.10]

18.00 [12.75,24.53]

16.70 [12.28,22.25]

18.00 [13.20,22.80]

21.70 [14.80,35.60]

0.03

AST (U/L)

20.30 [16.50, 24.87]

20.40 [16.65,26.22]

19.45 [16.32,24.13]

19.80 [16.50,23.90]

21.90 [16.50,26.10]

0.64

Bun (mg/mL)

14.56 [11.76, 17.64]

14.98 [11.76,17.92]

14.00 [11.97,16.66]

14.56 [11.76,17.36]

14.84 [12.04,18.20]

0.83

Creatinine (umol/L)

73.00 [63.00, 82.00]

74.00 [63.00,82.00]

68.50 [62.00,78.00]

74.00 [63.00,86.00]

74.00 [67.00,82.00]

0.13

UA (umol/L)

330.50 [270.25, 392.50]

327.00 [264.75,382.75]

301.00 [232.00,354.25]

334.00 [281.00,371.00]

378.00 [312.00,435.00]

< 0.01

Glucose (mmol/L)

5.63 [5.17, 6.50]

5.50 [5.14,5.98]

5.79 [5.08,6.43]

5.70 [5.17,6.67]

5.84 [5.27,6.87]

0.12

Cholesterol (mmol/L)

3.97 [3.30, 4.75]

3.96 [3.44,4.83]

3.97 [3.28,4.55]

3.81 [3.28,4.41]

4.16 [3.31,5.14]

0.49

Triglyceride (mmol/L)

1.29 [0.95, 1.84]

0.84 [0.69,0.95]

1.08 [0.98,1.31]

1.44 [1.23,1.80]

2.30 [1.89,2.79]

< 0.01

HDL (mmol/L)

1.09 [0.91, 1.31]

1.38 [1.20,1.53]

1.10 [0.99,1.31]

1.01 [0.88,1.20]

0.90 [0.80,1.03]

< 0.01

LDL (mmol/L)

2.15 [1.64, 2.71]

2.17 [1.63,2.94]

2.30 [1.70,2.78]

2.12 [1.88,2.59]

1.94 [1.51,2.69]

0.48

HbA1c (%)

6.10 [5.80, 6.80]

5.95 [5.60,6.50]

6.10 [5.70,6.60]

6.30 [5.80,7.10]

6.40 [5.80,6.90]

0.07

Coronary artery examination

Diameter stenosis %

LAD

29.55 (23.18, 35.48)

27.20 (22.07,32.50)

30.00 (23.27,36.92)

29.70 (25.60,33.80)

30.50 (24.50,36.10)

0.12

LCX

28.50 (22.25, 36.55)

27.15 (20.95,34.92)

29.90 (22.40,36.33)

28.70 (22.60,37.00)

29.00 (22.70,36.40)

0.77

RCA

22.80 (16.12, 29.80)

23.25 (16.00,29.07)

22.35 (15.95,31.92)

21.70 (16.50,28.20)

23.10 (17.00,30.20)

0.93

QFR

LAD

0.92 [0.87, 0.96]

0.93 [0.87,0.96]

0.92 [0.87,0.95]

0.93 [0.87,0.95]

0.92 [0.88,0.96]

0.87

LCX

0.95 [0.89, 0.97]

0.95 [0.89,0.97]

0.95 [0.90,0.97]

0.94 [0.89,0.97]

0.95 [0.90,0.97]

0.99

RCA

0.98 [0.94, 0.99]

0.98 [0.94,0.99]

0.97 [0.95,0.99]

0.98 [0.95,0.99]

0.98 [0.95,0.99]

0.84

AMR (mmHg*s/m)

LAD

270.00 [234.25, 310.00]

248.50 [228.25,310.25]

278.00 [240.00,309.25]

263.00 [238.00,301.00]

291.00 [238.00,316.00]

0.52

LCX

262.50 [236.00, 316.75]

247.50 [233.25,297.75]

258.00 [244.00,304.00]

263.00 [235.00,321.00]

286.00 [237.00,321.00]

0.42

RCA

252.00 [228.00, 291.75]

242.50 [218.50,272.25]

242.50 [224.00,280.25]

268.00 [241.00,292.00]

268.00 [233.00,306.00]

0.03

  1. CMVD Coronary microvascular disease, CAD coronary artery disease, CCB calcium channel blocker, CRP C-reaction protein, CLR C-reaction protein to lymphocyte ratio, IBI inflammatory burden index, TG/HDL triglycerides to high-density lipoprotein cholesterol ratio, CK-MB creatine kinase isoenzyme-MB, BNP brain natriuretic peptide, ALT alanine aminotransferase, AST aspartate aminotransferase, BUN blood urea nitrogen, BUN blood urea nitrogen, UA uric acid, HDL high-density lipoprotein cholesterol, LDL low density lipoprotein, HBA1c hemoglobin A1c, LAD the left anterior descending coronary artery, LCX circumflex branch of left coronary artery, RCA right coronary artery, QFR quantitative flow ratio, AMR angiographic microvascular resistance.
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