Table 4 Effect of Morin hydrate on the anticancer activity and cytotoxicity of Cisplatin.

From: Morin hydrate protects against cisplatin-induced testicular toxicity by modulating ferroptosis and steroidogenesis genes’ expression and upregulating Nrf2/Heme oxygenase-1

Compound

IC50 MCF-7

IC50 Mcf10A

Selectivity Index (SI)

CIS

6.29 ± 1.29

4.06 ± 2.55

0.64

M

45 ± 0.7

862.25 ± 59

19.16

CM

4.29 ± 2.0

78.47 ± 1.39

18.29

  1. The table shows the IC50 values in µM reflecting the cytotoxic activity of cisplatin, morin Hydrate and their combination in MCF-7 and non-cancerous MCF10A cells along with the selectivity index (SI). CIS cisplatin, CM cisplatin and morin hydrate, M morin hydrate, MCF10a noncancerous Breast Cancer cell line, MCF-7 Human Breast Cancer Cell Line.
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