Fig. 2

MP mice had elevated systolic blood pressure (SBP), chronic hypertension coupled with myocyte hypertrophy vs. NP mice. (A) MP mice had elevated SBP. Echocardiography analysis was suggestive of a chronic hypertension phenotype as indicated by (B) increased end diastolic volume- EDV, (C) end systolic volume-ESV, (D) reduced ejection fraction—EF%, (E) and fractional shortening-FS %, and (F) prolonged isovolumetric relaxation time- IVRT, in MP mice. (G) Myocyte size was increased with increased gene expression of (H) alpha myosin heavy chain- Myh6, and (I) atrial natriuretic peptide-Nppa. There were no significant changes in mRNA expression of (J) β myosin light chain- Myh7, and (K) brain natriuretic peptide- Nppb in MP mice. MP, n = 8, NP, n = 8. *P < 0.05, **P < 0.005, ns = P > 0.05, MP vs NP. Unpaired two tailed t-test, with Mann–Whitney test for post hoc analysis. Data presented as ± SEM.